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Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research

  • Ben Shirt-Ediss,
  • Sara Murillo-Sánchez and
  • Kepa Ruiz-Mirazo

Beilstein J. Org. Chem. 2017, 13, 1388–1395, doi:10.3762/bjoc.13.135

Graphical Abstract
  • experimental challenges aimed at constructing protocell systems made of a diversity of functionally coupled components and, thereby, at characterizing more precisely the type of prebiotic evolutionary dynamics that such protocells could engage in. Keywords: functional integration; origins of life; prebiotic
  • move the field of origins of life forward would be to couple simple chemistry to prebiotic vesicle dynamics: chemical reactions provide the power for endogenous synthesis and vesicles the adequate scaffolding for the functional integration of what is synthesized. We will proceed briefly with the issue
  • of functional integration below, but the main point to highlight here is that both for reactive processes to become proto-metabolic and for vesicles to become proto-cellular, their mutual, dynamic engagement could well be an early, unavoidable requirement [40]. As Szostak [41] has also noted, the
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Published 13 Jul 2017
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